Kidney disease elevates creatinine and uric acid. According to the National Institute of Diabetes and Digestive and Kidney Diseases, or NIDDK, over 100,000 Americans are diagnosed with kidney disease each year. Kidney disease, also known as kidney failure, is a serious condition that impairs the kidneys to rid your body of metabolic waste products. Kidney failure is the end-stage of chronic kidney disease. Common signs and symptoms associated with kidney disease include elevated creatinine and uric acid levels, decreased urine output, nausea, vomiting, decreased appetite, fatigue, weakness, sleep problems, reduced mental sharpness, muscle cramps, swelling of your feet and ankles and persistent itching. The NIDDK states that diabetes and hypertension are the most common causes of kidney disease, although other conditions can also cause kidney failure.